Back to Search
Start Over
Weight and leptin changes among risperidone-treated youths with autism: 6-month prospective data.
- Source :
- American Journal of Psychiatry; Jun2004, Vol. 161 Issue 6, p1125-1127, 3p
- Publication Year :
- 2004
-
Abstract
- OBJECTIVE: The authors examined the developmental impact and temporal characteristics of risperidone-associated weight change. METHOD: Weight change was measured for 63 children and adolescents with autism treated with risperidone for 6 months. Change in serum leptin levels after 2 months was examined as a predictor of final weight gain in mixed regression models that controlled for site, gender, age, and risperidone dose. RESULTS: Age- and gender-standardized weight increased after 6 months of treatment (gross: mean=5.6 kg [SD=3.9]; standardized: mean=0.6 z [SD=0.5]) and was positively correlated with weight gained after 1 month. Change in leptin levels after 2 months of treatment (mean=-0.3 ng/ml, SD=6.2) (N=48) did not predict final weight gain. CONCLUSIONS: Chronic risperidone exposure in children with autism causes weight gain in excess of developmentally expected norms that follows a curvilinear trajectory and decelerates over time. Serum leptin change does not reliably predict risperidone-associated weight gain. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0002953X
- Volume :
- 161
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- American Journal of Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 106531717
- Full Text :
- https://doi.org/10.1176/appi.ajp.161.6.1125