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App Gene Dosage Modulates Endosomal Abnormalities of Alzheimer's Disease in a Segmental Trisomy 16 Mouse Model of Down Syndrome.
- Source :
- Journal of Neuroscience; 7/30/2003, Vol. 23 Issue 17, p6788, 5p, 4 Black and White Photographs
- Publication Year :
- 2003
-
Abstract
- Discusses a study which showed that a genetic model of Down syndrome increased immunoreactivity for makers of endosome fusion and endosome recycling. Abnormalities that are prominent in neurons of the basal forebrain; Factor considered the early known pathology in sporadic Alzheimer's disease; Role essential for App gene triplication.
- Subjects :
- GENETICS
DOWN syndrome
PATHOLOGY
ALZHEIMER'S disease
NERVOUS system
Subjects
Details
- Language :
- English
- ISSN :
- 02706474
- Volume :
- 23
- Issue :
- 17
- Database :
- Complementary Index
- Journal :
- Journal of Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 10639402
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.23-17-06788.2003