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A fraction of Acorus calamus L. extract devoid of beta-asarone enhances adipocyte differentiation in 3T3-L1 cells.

A fraction of Acorus calamus L. extract devoid of beta-asarone enhances adipocyte differentiation in 3T3-L1 cells.

Authors :
Wu H
Li Y
Weng L
Zhou C
He Q
Lou Y
Wu, Hao-shu
Li, Ying-yin
Weng, Lin-jia
Zhou, Chang-xin
He, Qiao-jun
Lou, Yi-jia
Source :
Phytotherapy Research; Jun2007, Vol. 21 Issue 6, p562-564, 3p
Publication Year :
2007

Abstract

The effects of fractions partitioned from the ethanol extract of Acorus calamus L. (AC) on adipocyte differentiation were investigated using cultured mouse 3T3-L1 preadipocytes. The degree of differentiation was evaluated by measuring the cellular triglycerides and protein expression of the glucose transporter GLUT4 in 3T3-L1 cells. The ethyl acetate fraction of the AC extract (ACE) was found to enhance adipocyte differentiation as did rosiglitazone. The results of further fractionation of ACE indicated that the active fraction does not consist of beta-asarone, which is a toxic component of this plant. This finding suggests that ACE has potential insulin-sensitizing activity like rosiglitazone, and may improve type 2 diabetes. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0951418X
Volume :
21
Issue :
6
Database :
Complementary Index
Journal :
Phytotherapy Research
Publication Type :
Academic Journal
Accession number :
106170778