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Methotrexate toxicity presenting as ulceration of psoriatic plaques: a report of two cases.
- Source :
- Indian Journal of Dermatology, Venereology & Leprology; Sep/Oct2008, Vol. 74 Issue 5, p481-484, 4p
- Publication Year :
- 2008
-
Abstract
- We describe two cases of methotrexate toxicity occurring due to inappropriate self-medication with the drug. The first patient was a 57-year-old man with plaque-type psoriasis on intermittent methotrexate therapy. He discontinued his medications for 2 months and had exacerbation of psoriasis for which he self-medicated with methotrexate following which he developed ulceration of the psoriatic plaques accompanied by bone marrow suppression. The second patient was a 68-year-old man with chronic plaque-type psoriasis for 20 years and was being treated with intermittent methotrexate for 15 years. He also self medicated with oral methotrexate 15 mg daily for 7 days for exacerbation of psoriasis and developed ulceration of the psoriatic plaques with bone marrow suppression and evidence of gastrointestinal erosions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03786323
- Volume :
- 74
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Indian Journal of Dermatology, Venereology & Leprology
- Publication Type :
- Academic Journal
- Accession number :
- 105585668