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Association between birth weight and adolescent systolic blood pressure in a caucasian birth cohort differs according to skin type, CRH promoter or 11beta-HSD2 genotype.
- Source :
- Archives of Disease in Childhood; Sep2008, Vol. 93 Issue 9, p760-767, 8p
- Publication Year :
- 2008
-
Abstract
- OBJECTIVE: To examine whether the inverse association between birth weight and blood pressure varies by skin pigmentation and/or related genotypes. Study DESIGN: 671 children from a predominantly caucasian birth cohort were followed-up to adolescence (mean (SD) age 14.4 (0.64)). METHODS: Data on birth weight, socioeconomic status, maternal antenatal smoking, adolescent blood pressure and polymorphisms of candidate genes were obtained and analysed by multiple linear regression. RESULTS: An increase in birth weight of 1 kg was associated with an non-significant difference in adolescent systolic blood pressure of -0.53 mm Hg (95% CI -1.72 to 0.66) per kg after adjustment for child age and cohort entry criteria. The inverse association between birth weight and systolic blood pressure was stronger for those with darker skin (> or =2% melanin) (difference in effect, p = 0.02), those with more copies of the C allele of corticotropin-releasing hormone (CRH) +T1273C (p = 0.06), and those with more copies of the short (< or =236 bp) form of the 11beta-HSD2{CA}n(repeat) microsatellite (p = 0.03). CONCLUSIONS: These findings add to the evidence that cortisol-related pathways may account for at least part of the observed birth weight-blood pressure associations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00039888
- Volume :
- 93
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Archives of Disease in Childhood
- Publication Type :
- Academic Journal
- Accession number :
- 105550600
- Full Text :
- https://doi.org/10.1136/adc.2007.129122