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GOLPH2 expression in renal cell cancer.
- Source :
- BMC Urology; 2008, Vol. 8, p15-15, 1p
- Publication Year :
- 2008
-
Abstract
- <bold>Background: </bold>Renal cell carcinomas (RCC) are among the most common and most lethal genitourinary malignancies. GOLPH2 (golgi phosphoprotein 2, GOLM1) has recently been proposed as a biomarker for hepatocellular and prostate cancer. In this study we analysed the expression patterns and the prognostic and diagnostic value of GOLPH2 in RCC.<bold>Methods: </bold>GOLPH2 protein expression was analysed by immunohistochemistry in 104 clinically well characterized RCC cases in comparison with matched normal kidney tissue and in association with clinico-pathological parameters. Statistical analyses including Kaplan Meier analyses were performed with SPSS version 15.0.<bold>Results: </bold>GOLPH2 was highly expressed in normal renal tubules and in almost half of RCC with a statistically significant predominance in the papillary and chromophobe histological subtypes. No other associations with clinico-pathological parameters were detectable. The Kaplan-Meier curves showed a weak trend for unfavourable prognosis of tumours with high GOLPH2 expression, but failed significance.<bold>Conclusion: </bold>GOLPH2 protein is expressed in normal renal tissue (especially in distal tubular epithelia) and is down-regulated in the majority of clear cell RCC. In papillary and chromophobe RCC GOLPH2 expression is consistently present. In contrast to its diagnostic value in hepatocellular and prostatic carcinomas, a prognostic or diagnostic value of GOLPH2 in RCC appears to be unlikely. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14712490
- Volume :
- 8
- Database :
- Complementary Index
- Journal :
- BMC Urology
- Publication Type :
- Academic Journal
- Accession number :
- 105530675
- Full Text :
- https://doi.org/10.1186/1471-2490-8-15