Activity-Dependent Trafficking and Dynamic Localization of Zipcode Binding Protein 1 and Β-Actin mRNA in Dendrites and Spines of Hippocampal Neurons.

Presents information on a study which used fluorescence microscopy and digital imaging techniques applied to both fixed and live cultured hippocampal neurons to visualize the localization of the messenger RNA binding protein, zipcode binding protein 1 (ZBP1) and its dynamic movements. Visualization of ZBP1 granules in dendrites, actin-rich spines and subsynaptic loci with the use of high-resolution fluorescence microscopy; Localization of ZBP1 in dendrites and spines with the use of high-resolution fluorescence imaging; Regulation of messenger RNA localization by neuronal activity and glutamatergic signals.