[gamma]-Secretase component presenilin is important for microglia [beta]-amyloid clearance.

The cleavage of amyloid precursor protein by [gamma]-secretase is an important aspect of the pathogenesis of Alzheimer's disease. [gamma]-Secretase also cleaves other membrane proteins (eg, Notch), which control cell development and homeostasis. Presenilin 1 and 2 are considered important determinants of the [gamma]-secretase catalytic site. Our aim was to investigate whether [gamma]-secretase can be important for microglial phagocytosis of Alzheimer's disease [beta]-amyloid. [ABSTRACT FROM AUTHOR]