A Mutation in Af4 Is Predicted to Cause Cerebellar Ataxia and Cataracts in the Robotic Mouse.

Presents information on a study which demonstrated a mutant mouse model for cerebellar ataxia that develops Purkinje cell loss in a stereotypical region-specific manner. Histology and immunohistochemistry; Identification of robotic mice which develop region-specific Purkinje cell loss; Neurodegenerative changes in the robotic cerebellum.