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ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium.
- Source :
- Cancer Causes & Control; Nov2012, Vol. 23 Issue 11, p1805-1810, 6p
- Publication Year :
- 2012
-
Abstract
- <bold>Purpose: </bold>Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results.<bold>Methods: </bold>In eight studies participating in the Ovarian Cancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis.<bold>Results: </bold>Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI: 0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes.<bold>Conclusion: </bold>Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09575243
- Volume :
- 23
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Cancer Causes & Control
- Publication Type :
- Academic Journal
- Accession number :
- 104383615
- Full Text :
- https://doi.org/10.1007/s10552-012-0059-y