A dominant negative form of the AAA ATPase SKD1/VPS4 impairs membrane trafficking out of endosomal/lysosomal compartments: class E vps phenotype in mammalian cells.

Demonstrates the participation of SKD1, a member of the family of ATPAses in the membrane transport from early endosomes to late endosomes/lysosomes. Steps of membrane transport; Reformation of lysosomes from a hybrid organelle; Role of ATPases in membrane transport.