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Using the bootstrap to establish statistical significance for relative validity comparisons among patient-reported outcome measures.
- Source :
- Health & Quality of Life Outcomes; 2013, Vol. 11 Issue 1, p89-89, 1p
- Publication Year :
- 2013
-
Abstract
- <bold>Background: </bold>Relative validity (RV), a ratio of ANOVA F-statistics, is often used to compare the validity of patient-reported outcome (PRO) measures. We used the bootstrap to establish the statistical significance of the RV and to identify key factors affecting its significance.<bold>Methods: </bold>Based on responses from 453 chronic kidney disease (CKD) patients to 16 CKD-specific and generic PRO measures, RVs were computed to determine how well each measure discriminated across clinically-defined groups of patients compared to the most discriminating (reference) measure. Statistical significance of RV was quantified by the 95% bootstrap confidence interval. Simulations examined the effects of sample size, denominator F-statistic, correlation between comparator and reference measures, and number of bootstrap replicates.<bold>Results: </bold>The statistical significance of the RV increased as the magnitude of denominator F-statistic increased or as the correlation between comparator and reference measures increased. A denominator F-statistic of 57 conveyed sufficient power (80%) to detect an RV of 0.6 for two measures correlated at r = 0.7. Larger denominator F-statistics or higher correlations provided greater power. Larger sample size with a fixed denominator F-statistic or more bootstrap replicates (beyond 500) had minimal impact.<bold>Conclusions: </bold>The bootstrap is valuable for establishing the statistical significance of RV estimates. A reasonably large denominator F-statistic (F > 57) is required for adequate power when using the RV to compare the validity of measures with small or moderate correlations (r < 0.7). Substantially greater power can be achieved when comparing measures of a very high correlation (r > 0.9). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14777525
- Volume :
- 11
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Health & Quality of Life Outcomes
- Publication Type :
- Academic Journal
- Accession number :
- 104228486
- Full Text :
- https://doi.org/10.1186/1477-7525-11-89