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Circulating PD- L1 in NSCLC patients and the correlation between the level of PD- L1 expression and the clinical characteristics.
- Source :
- Thoracic Cancer; Jul2015, Vol. 6 Issue 4, p534-538, 5p
- Publication Year :
- 2015
-
Abstract
- Background The programmed cell death-1/programmed cell death-1 ligand ( PD-1/ PD- L1) pathway plays a crucial role in tumor evasion. This study evaluated the association between circulating PD-L1 expression and clinical characteristics in patients with advanced non-small cell lung cancer ( NSCLC). Methods A total of 109 advanced NSCLC and 65 healthy patients from the Beijng Cancer Hospital were enrolled in the study. Circulating PD- L1 expression was tested by enzyme-linked immunosorbent assay. The associations between the level of PD- L1 expression and clinicopathologic features and prognosis were statistically analyzed. Results The expression of PD- L1 in advanced NSCLC patients was significantly upregulated compared with the healthy control ( P < 0.001). The expression of PD-L1 was significantly correlated with abdominal organ metastasis ( P = 0.004). A high PD- L1 expression had a worse prognosis than a low expression in patients (18.7 vs. 26.8 month, P < 0.001). Conclusions PD- L1 was elevated in advanced NSCLC patients and may play an important role in tumor immune evasion and patient prognosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- ACADEMIC medical centers
APOPTOSIS
BLOOD testing
CONFIDENCE intervals
ENZYME-linked immunosorbent assay
IMMUNOHISTOCHEMISTRY
IMMUNOTHERAPY
LUNG cancer
LOGISTIC regression analysis
RETROSPECTIVE studies
SEVERITY of illness index
RECEIVER operating characteristic curves
DATA analysis software
DESCRIPTIVE statistics
KAPLAN-Meier estimator
Subjects
Details
- Language :
- English
- ISSN :
- 17597706
- Volume :
- 6
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Thoracic Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 103641769
- Full Text :
- https://doi.org/10.1111/1759-7714.12247