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Construction of a Chiral Silicon Center by Rhodium-Catalyzed Enantioselective Intramolecular Hydrosilylation.
- Source :
- Chemistry - A European Journal; Jun2015, Vol. 21 Issue 26, p9319-9322, 4p
- Publication Year :
- 2015
-
Abstract
- Rhodium-catalyzed enantioselective desymmetrizing intramolecular hydrosilylation of symmetrically disubstituted hydrosilanes is described. The original axially chiral phenanthroline ligand ( S)-BinThro (Binol-derived phenanthroline) was found to work as an effective chiral catalyst for this transformation. A chiral silicon stereogenic center is one of the chiral motifs gaining much attention in asymmetric syntheses and the present protocol provides cyclic five-membered organosilanes incorporating chiral silicon centers with high enantioselectivities (up to 91 % ee). The putative active Rh<superscript>I</superscript> catalyst takes the form of an N, N, O-tridentate coordination complex, as determined by several complementary experiments. [ABSTRACT FROM AUTHOR]
- Subjects :
- SILICON
RHODIUM
CHEMICAL reactions
HYDROSILYLATION
NONMETALS
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 21
- Issue :
- 26
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 103342644
- Full Text :
- https://doi.org/10.1002/chem.201501568