Conservation of transcription factor binding specificities across 600 million years of bilateria evolution.

The article presents a study related to divergence morphology, conducted on Drosophila. This study determines the binding specificities of 242 Drosophila transcription factors (TFs), and compares them to human and mouse data. Discussing dinucleotide binding preferences and orthologous TFs, it is inferred that evolution of TF specificities contributes to emergence of novel types of differentiated cells.