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Factorial validity, measurement equivalence and cognitive performance of the Cambridge Neuropsychological Test Automated Battery (CANTAB) between patients with first-episode psychosis and healthy volunteers.
- Source :
- Psychological Medicine; Jul2015, Vol. 45 Issue 9, p1919-1929, 11p
- Publication Year :
- 2015
-
Abstract
- BackgroundThe purpose of this study was to use selected Cambridge Neuropsychological Test Automated Battery (CANTAB) tests to examine the dimensional structure of cognitive dysfunction in first episode of psychosis (FEP) patients compared with cognition in healthy subjects.MethodA total of 109 FEP patients and 96 healthy volunteers were administered eight CANTAB tests of cognitive function. Principal components analysis (PCA) was used to estimate dimensionality within the test results. The dimensions identified by the PCA were assumed to reflect underlying cognitive traits. The plausibility of latent factor models was estimated using confirmatory factor analysis (CFA). Multi-group CFA (MGCFA) was used to test for measurement invariance of factors between groups. The nature and severity of cognitive deficits amongst patients as opposed to controls were evaluated using a general linear model.ResultsAmongst subjects PCA identified two underlying cognitive traits: (i) a broad cognitive domain; (ii) attention/memory and executive function domains. Corresponding CFA models were built that fitted data well for both FEP patients and healthy volunteers. As in MGCFA latent variables appeared differently defined in patient and control groups, differences had to be ascribed using subtest scores rather than their aggregates. At subtest score level the patients performed significantly worse than healthy subjects in all comparisons (p < 0.001).ConclusionsResults of this study demonstrate that the structure of underlying cognitive abilities as measured by a selection of CANTAB tests is not the same for healthy individuals and FEP patients, with patients displaying widespread cognitive impairment. [ABSTRACT FROM AUTHOR]
- Subjects :
- PSYCHOSES
DIAGNOSIS of schizophrenia
ATTENTION
CHI-squared test
COGNITIVE testing
COMPARATIVE studies
STATISTICAL correlation
FACTOR analysis
GOODNESS-of-fit tests
NEUROPSYCHOLOGICAL tests
RESEARCH methodology
MEMORY
REPLICATION (Experimental design)
T-test (Statistics)
RESEARCH methodology evaluation
EXECUTIVE function
DATA analysis software
DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00332917
- Volume :
- 45
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Psychological Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 102874008
- Full Text :
- https://doi.org/10.1017/S0033291714003018