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Egg consumption and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.
- Source :
- American Journal of Clinical Nutrition; May2015, Vol. 101 Issue 5, p1088-1096, 9p, 1 Diagram, 4 Charts, 1 Graph
- Publication Year :
- 2015
-
Abstract
- BACKGROUND: The prevalence of type 2 diabetes (T2D) is increasing around the world. Eggs are a major source of cholesterol, which has been associated with elevated blood glucose and an increased risk of T2D. However, there are limited and conflicting data from prospective population studies on the association between egg consumption and risk of T2D. OBJECTIVE: We investigated the association between egg consumption and risk of incident T2D in middle-aged and older men from eastern Finland. DESIGN: The study included 2332 men aged 42-60 y in 1984-1989 at the baseline examinations of the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study. Dietary intakes were assessed with 4-d food records at baseline. Incident T2D was assessed by self-administered questionnaires; by fasting and 2-h oral-glucose-tolerance-test blood glucose measurement at re-examination rounds 4, 11, and 20 y after baseline; and by record linkage to a hospital discharge registry and reimbursement register of diabetes medication expenses. Cox proportional hazards regression analyses were used to estimate associations with the risk of incident T2D. Associations with the metabolic risk markers at baseline and at the 4-y examinations were analyzed by ANCOVA. RESULTS: During an average follow-up of 19.3 y, 432 men developed T2D. After adjustment for potential confounders, those in the highest compared with the lowest egg intake quartile had a 38% (95% CI: 18%, 53%; P-trend across quartiles <0.001) lower risk of incident T2D. Analyses with metabolic risk markers also suggested an inverse association with fasting plasma glucose and serum C-reactive protein but not with serum insulin. The associations between cholesterol intake and risk of T2D, plasma glucose, serum insulin, and C-reactive protein were mainly nonsignificant, especially after accounting for egg consumption. CONCLUSION: Higher egg intake was associated with a lower risk of T2D in this cohort of middle-aged and older men. [ABSTRACT FROM AUTHOR]
- Subjects :
- BLOOD sugar analysis
TYPE 2 diabetes risk factors
SMOKING
EGGS
GERIATRIC nutrition
ANALYSIS of covariance
APOLIPOPROTEINS
C-reactive protein
CHI-squared test
CONFIDENCE intervals
REPORTING of diseases
ALCOHOL drinking
EPIDEMIOLOGICAL research
CHOLESTEROL content of food
GLUCOSE tolerance tests
INGESTION
INSULIN
LONGITUDINAL method
MEN'S health
TYPE 2 diabetes
NUTRITIONAL assessment
PROBABILITY theory
QUESTIONNAIRES
REGRESSION analysis
RESEARCH funding
SELF-evaluation
STATISTICAL hypothesis testing
STATISTICS
PHENOTYPES
HEALTH insurance reimbursement
DATA analysis
BODY mass index
LIFESTYLES
PROPORTIONAL hazards models
FOOD diaries
PHYSICAL activity
DATA analysis software
DESCRIPTIVE statistics
ODDS ratio
MIDDLE age
Subjects
Details
- Language :
- English
- ISSN :
- 00029165
- Volume :
- 101
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 102811098
- Full Text :
- https://doi.org/10.3945/ajcn.114.104109