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HSV oropharyngeal shedding among HIV-infected children in Tanzania.

Authors :
Zuckerman, Richard
Manji, Karim
Matee, Mecky
Naburi, Helga
Bisimba, Jema
Martinez, Raquel
Wieland-Alter, Wendy
Kim, Faith
von Reyn, C Fordham
Palumbo, Paul
Source :
International Journal of STD & AIDS; Jun2015, Vol. 26 Issue 7, p456-461, 6p
Publication Year :
2015

Abstract

Herpes simplex virus (HSV) oral shedding has not been studied among HIV-positive children in Africa. We sought to evaluate longitudinal oral HSV reactivation in HIV-positive and -negative children. Twenty HIV-positive antiretroviral-naive and 10 HIV-negative children aged 3–12 years in Tanzania were followed prospectively for 14 days. Oral swabs were collected daily and submitted for HSV DNA PCR analysis. Clinical data were collected via chart review and daily diaries. HSV DNA was detected in 10 (50%) of HIV-positive and 4 (40%) of HIV-negative children. Children who shed HSV had virus detected in a median of 21.4% of samples; shedding was intermittent. Median CD4 count among HIV-infected children was 667 cells/µL in those with positive HSV DNA and 886 cells/µL in those who were negative (p = 0.6). Of the HIV-positive children reporting prior sores, five (83%) had positive HSV swabs, whereas the one HIV-negative child with prior sores did not have a PCR-positive swab. HSV is detected frequently in children with and without HIV. HIV-infected children reporting oral sores have a high rate of HSV detection. Given the proven strong interactions between HIV and HSV, further study of co-infection with these viruses is warranted in children. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09564624
Volume :
26
Issue :
7
Database :
Complementary Index
Journal :
International Journal of STD & AIDS
Publication Type :
Academic Journal
Accession number :
102659018
Full Text :
https://doi.org/10.1177/0956462414543122