Back to Search Start Over

Chemokine-guided cell migration and motility in zebrafish development.

Authors :
Bussmann, Jeroen
Raz, Erez
Source :
EMBO Journal; May2015, Vol. 34 Issue 10, p1309-1318, 10p, 1 Diagram, 1 Chart
Publication Year :
2015

Abstract

Chemokines are vertebrate-specific, structurally related proteins that function primarily in controlling cell movements by activating specific 7-transmembrane receptors. Chemokines play critical roles in a large number of biological processes and are also involved in a range of pathological conditions. For these reasons, chemokines are at the focus of studies in developmental biology and of clinically oriented research aimed at controlling cancer, inflammation, and immunological diseases. The small size of the zebrafish embryos, their rapid external development, and optical properties as well as the large number of eggs and the fast expansion in genetic tools available make this model an extremely useful one for studying the function of chemokines and chemokine receptors in an in vivo setting. Here, we review the findings relevant to the role that chemokines play in the context of directed single-cell migration, primarily in neutrophils and germ cells, and compare it to the collective cell migration of the zebrafish lateral line. We present the current knowledge concerning the formation of the chemokine gradient, its interpretation within the cell, and the molecular mechanisms underlying the cellular response to chemokine signals during directed migration. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02614189
Volume :
34
Issue :
10
Database :
Complementary Index
Journal :
EMBO Journal
Publication Type :
Academic Journal
Accession number :
102601512
Full Text :
https://doi.org/10.15252/embj.201490105