Back to Search
Start Over
Lessons learned from the clinical development of oral peptides.
- Source :
- British Journal of Clinical Pharmacology; May2015, Vol. 79 Issue 5, p720-732, 13p
- Publication Year :
- 2015
-
Abstract
- The oral delivery of peptides and proteins has been hampered by an array of obstacles. However, several promising novel oral delivery systems have been developed. This paper reviews the most advanced oral formulation technologies, and highlights key lessons and implications from studies undertaken to date with these oral formulations. Special interest is given to oral salmon calcitonin ( CT), glucagon-like peptide-1 ( GLP-1), insulin, PYY-(3-36), recombinant human parathyroid hormone ( rhPTH(1-31)- NH<subscript>2</subscript>) and PTH(1-34), by different technologies. The issues addressed include (i) interaction with water, (ii) interaction with food, (iii) diurnal variation, (iv) inter- and intra-subject variability, (v) correlation between efficacy and exposure and (vi) key deliverables of different technologies. These key lessons may aid research in the development of other oral formulations. [ABSTRACT FROM AUTHOR]
- Subjects :
- PEPTIDES
PROTEINS
CALCITONIN
GLUCAGON
PARATHYROID hormone
Subjects
Details
- Language :
- English
- ISSN :
- 03065251
- Volume :
- 79
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- British Journal of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 102186846
- Full Text :
- https://doi.org/10.1111/bcp.12557