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Neuroimaging indicators of the performance of instrumental activities of daily living in Alzheimer's disease combined with cerebrovascular disease.
- Source :
- Geriatrics & Gerontology International; May2015, Vol. 15 Issue 5, p588-593, 6p
- Publication Year :
- 2015
-
Abstract
- Objectives The aim of the present study was to explore the magnetic resonance imaging correlates of the performance of instrumental activities of daily living ( IADL) in patients with Alzheimer's disease combined with cerebrovascular disease. Methods A total of 66 patients with Alzheimer's disease combined with cerebrovascular disease formed the study sample. Two regression models were constructed to find correlates of IADL. Model 1 only included clinical variables and model 2 included both clinical and magnetic resonance imaging variables. Results In model 1, with IADL as the dependent variable, the Mini-Mental State Examination ( MMSE) score, Physical Self- Maintenance Scale score at baseline and age were significant correlates accounting for 40.1% of the variance of IADL at baseline. MMSE score and age were also significant correlates of IADL at 6 months, accounting for 38.1% of the variance of it. In model 2, severity of white matter lesions, MMSE and Physical Self- Maintenance Scale scores at baseline significantly correlated with IADL at baseline, accounting for 52.1% of the variance of the dependent variables; severity of white matter lesions and MMSE significantly correlated with IADL at 6 months, accounting for 41.5% of the variance of the dependent variables. Conclusion In patients with Alzheimer's disease combined with cerebrovascular disease, subcortical ischemic lesions might be significant contributor to the functional status. Geriatr Gerontol Int 2015; 15: 588-593. [ABSTRACT FROM AUTHOR]
- Subjects :
- BRAIN physiology
ELDER care
ALZHEIMER'S disease
CEREBROVASCULAR disease
COGNITIVE testing
STATISTICAL correlation
FORECASTING
LIFE skills
MAGNETIC resonance imaging
NEUROPSYCHOLOGICAL tests
PROBABILITY theory
REGRESSION analysis
RESEARCH evaluation
RESEARCH funding
STATISTICAL hypothesis testing
STATISTICS
DATA analysis
ACTIVITIES of daily living
MULTIPLE regression analysis
INTER-observer reliability
BLIND experiment
SEVERITY of illness index
DATA analysis software
FUNCTIONAL assessment
DESCRIPTIVE statistics
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 14441586
- Volume :
- 15
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Geriatrics & Gerontology International
- Publication Type :
- Academic Journal
- Accession number :
- 102168024
- Full Text :
- https://doi.org/10.1111/ggi.12323