Related Factors of Hyperhomocysteinemia among Non-hypertensive People Aged between 40-70 Years in Tianjin.

Objective To investigate the concentration of homocysteine (Hcy) and related factors of hyperhomocysteinemia (hHcy,Hcy⩾15 μmol/L) among non-hypertensive people aged between 40-70 in Tianjin. Methods Non-hypertensive community residents aged 40-70 years were enrolled randomly from May 2011 to December 2012 in six districts in Tianjin. Plasma Hcy was assessed by enzyme cycling method. Factors related to hHcy were analyzed in multivariate logistic re-gression models. Results Our study included 874 participants (mean age is 57 ± 6 years, 25.5% of all are males) and the concentration of Hcy was 12.0 μmol/L. The OR (odds ratio) (95% CI; P)for hHcy were 1.048(.015,1.083; P=0.004), 4.191 (2.359,7.448; P<0.001), 1.280(0.896,1.829; P=0.175), 0.460(0.259,0.816; P=0.008)respectively for age, male, smoking, exercise, and the odd ratio for hHcy were 0.290(0.179, 0.469; P < 0.001), 0.168(0.092,0.309; P < 0.001)for consumption of vegetable and fruits 250-500 g/d and >500g/d, compared with <250 g/d. Conclusion Male and age were adverse factors for hHcy, consumption of vegetable and fruits, and exercise were positive factors. [ABSTRACT FROM AUTHOR]