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Conversion of Unresectable Metastatic Colorectal Cancer.

Authors :
Dunne, Declan F. J.
Jones, Robert P.
Malik, Hassan Z.
Fenwick, Stephen W.
Poston, Graeme J.
Source :
Journal of OncoPathology; Dec2013, Vol. 1 Issue 4, p91-98, 8p
Publication Year :
2013

Abstract

The majority of patients diagnosed with colorectal cancer have either metastatic disease at presentation or subsequently develop metastases. In patients with resectable metastases the prognosis is good with approximately 50% of patients surviving 5 years. Unfortunately the majority of patients are not suitable for surgery with curative intent at the time of presentation. Utilizing multimodal therapies a number of patients have been successfully converted to potentially curative surgery, and survival in these patients has been shown to be comparable to patients with initially resectable disease. Over the past two decades, the expansion of therapeutic options for treating colorectal cancer has meant it is increasingly feasible to convert patients with initially irresectable disease to curative intent surgery. The successful navigation of this pathway relies of appropriate timed and delivered therapy. This strategy involves accurate staging, and treatment that can include systemic chemotherapy, hepatic artery chemotherapy, chemoembolization, thoracic surgery, and advanced hepatic surgical techniques. Achieving high rates of conversion should be seen as a marker of successful multidisciplinary team working and highquality clinical care. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20525931
Volume :
1
Issue :
4
Database :
Complementary Index
Journal :
Journal of OncoPathology
Publication Type :
Academic Journal
Accession number :
102146120
Full Text :
https://doi.org/10.13032/tjop.2052-5931.100064