EBC-316, 325-327, and 345: New Pimarane Diterpenes from Croton insularis Found in the Australian Rainforest.

Authors :: Maslovskaya, Lidia A.
Savchenko, Andrei I.
Gordon, Victoria A.
Reddell, Paul W.
Pierce, Carly J.
Parsons, Peter G.
Williams, Craig M.
Source :: Australian Journal of Chemistry; 2015, Vol. 68 Issue 4, p652-659, 51p, 10 Charts
Publication Year :: 2015
Abstract: Five new pimarane and related-type diterpenes (i.e. EBC-316, 325-327, and 345 (10-15)), together with two known pimaranes (EBC-221 (8) and EBC-346 (9)), were isolated from the stems of Croton insularis, found in the Australian rainforest. All pimarane diterpenes disclosed herein are suggested to be biogenetically related to the same keto-Jacobs- Reynolds intermediate 2, via ring A and C oxidation. Anticancer activities of compounds 11-13 are reported. [ABSTRACT FROM AUTHOR]

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