Therapeutic drug monitoring of voriconazole: validation of a novel ARK™ immunoassay and comparison with ultra-high performance liquid chromatography.

The article discusses a study which evaluated the efficacy of voriconazole (VRC) in treating fungal infections. Topics covered include the major determinants of variability of VRC plasma concentrations such as oral bioavailability and VRC pharmacokinetics, an overview of the analytical methods for measuring VRC in plasma including bioassays, and the linearity of the VRC assay.