Back to Search
Start Over
Evaluation of Plasma Exchange and Continuous Veno-Venous Hemofiltration for the Treatment of Severe Avian Influenza A ( H7N9): A Cohort Study.
- Source :
- Therapeutic Apheresis & Dialysis; Apr2015, Vol. 19 Issue 2, p178-184, 7p
- Publication Year :
- 2015
-
Abstract
- Avian influenza A ( H7N9) is a severe disease with high mortality. Hypercytokinemia is thought to play an important role in the pathogenesis. This study was to investigate the efficiency of plasma exchange ( PE) + continuous veno-venous hemofiltration ( CVVH) on the removal of inflammatory mediators and their benefits in the management of fluid overload and metabolic disturbance. In total, 40 H7N9-infected patients were admitted to our hospital. Sixteen critically ill H7N9-infected patients received combination of PE and CVVH. Data from these 16 patients were collected and analyzed. The effects of PE + CVVH on plasma cytokine/chemokine levels and clinical outcomes were examined. H7N9-infected patients had increased plasma levels compared to healthy controls. After 3 h of PE + CVVH treatment, the cytokine/chemokine levels descended remarkably to lower levels and were maintained thereafter. PE + CVVH also benefited the management of fluid, cardiovascular dysfunction and metabolic disturbance. Of the 16 critically ill patients who received PE + CVVH, 10 patients survived. PE + CVVH decreased the plasma cytokine/chemokine levels significantly. PE + CVVH were also beneficial to the management of severe avian influenza A ( H7N9). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17449979
- Volume :
- 19
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Therapeutic Apheresis & Dialysis
- Publication Type :
- Academic Journal
- Accession number :
- 102013926
- Full Text :
- https://doi.org/10.1111/1744-9987.12240