Change of IL-6 in Lyme Arthritis Induced by BmpA of Borrelia burgdorferi.

Objective To investigate the change of IL-6 in Lyme arthritis. Methods Twenty female Kunming mice were selected and randomly divided into two groups. The recombinant BmpA of Borrelia burgdorferi was injected into the tibiotarsal joint of experimental group mice to induce the arthritis. ELISA experiment was used to detect the concentration of IL-6 in murine joints. Results The average concentration of IL-6 in the joint fluid of experimental mice and normal control group was 72.26 pg/mL and 31.32 pg/mL, respectively. The difference was statistically significant between two groups (P < 0.01). Conclusion IL-6 is a important inflammatory cytokine, it has obvious correlation with Lyme arthritis. [ABSTRACT FROM AUTHOR]