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Ultrasound-Driven Secondary Self-Assembly of Amphiphilic β-Cyclodextrin Dimers.
- Source :
- Chemistry - A European Journal; Mar2015, Vol. 21 Issue 13, p5000-5008, 9p
- Publication Year :
- 2015
-
Abstract
- The controlled secondary self-assembly of amphiphilic molecules in solution is theoretically and practically significant in amphiphilic molecular applications. An amphiphilic β-cyclodextrin (β-CD) dimer, namely LA-(CD)<subscript>2</subscript>, has been synthesized, wherein one lithocholic acid (LA) unit is hydrophobic and two β-CD units are hydrophilic. In an aqueous solution at room temperature, LA-(CD)<subscript>2</subscript> self-assembles into spherical micelles without ultrasonication. The primary micelles dissociates and then secondarily form self-assemblies with branched structures under ultrasonication. The branched aggregates revert to primary micelles at high temperature. The ultrasound-driven secondary self-assembly is confirmed by transmission electron microscopy, dynamic light scattering, <superscript>1</superscript>H NMR spectroscopy, and Cu<superscript>2+</superscript>-responsive experiments. Furthermore, 2D NOESY NMR and UV/Vis spectroscopy results indicate that the formation of the primary micelles is driven by hydrophilic-hydrophobic interactions, whereas host-guest interactions promote the formation of the secondary assemblies. Additionally, ultrasonication is shown to be able to effectively destroy the primary hydrophilic-hydrophobic balances while enhancing the host-guest interaction between the LA and β-CD moieties at room temperature. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 21
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 101516658
- Full Text :
- https://doi.org/10.1002/chem.201405707