ERG deletion is associated with CD2 and attenuates the negative impact of IKZF1 deletion in childhood acute lymphoblastic leukemia.

Authors :: Zaliova, M
Zimmermannova, O
Dörge, P
Eckert, C
Möricke, A
Zimmermann, M
Stuchly, J
Teigler-Schlegel, A
Meissner, B
Koehler, R
Bartram, C R
Karawajew, L
Rhein, P
Zuna, J
Schrappe, M
Cario, G
Stanulla, M
Source :: Leukemia (08876924); Jan2014, Vol. 28 Issue 1, p182-185, 4p, 2 Charts, 1 Graph
Publication Year :: 2014
Abstract: The article presents a study which analyzes the presence of ERGdel gene coding in a large cohort of children with acute lymphoblastic leukemia (ALL) treated according to the Austrian-German-Swiss ALL-BFM-2000 protocol. It mentions the clonal stability of ERGdel from diagnosis to relapse in paired samples that occurred at a frequency of 4.5% in childhood ALL. The authors note that their observations support a positive impact of ERGdel on treatment susceptibility in ALL-BFM 2000.

Subjects :: GENETIC code
LYMPHOBLASTIC leukemia in children
MEDICAL protocols
CLONE cells
DELETION mutation

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