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Pharmacokinetics of oral transmucosal and intramuscular dexmedetomidine combined with buprenorphine in cats.
- Source :
- Journal of Veterinary Pharmacology & Therapeutics; Apr2015, Vol. 38 Issue 2, p203-208, 6p
- Publication Year :
- 2015
-
Abstract
- Plasma concentrations and pharmacokinetics of dexmedetomidine and buprenorphine after oral transmucosal ( OTM) and intramuscular (i.m.) administration of their combination in healthy adult cats were compared. According to a crossover protocol (1-month washout), a combination of dexmedetomidine (40 μg/kg) and buprenorphine (20 μg/kg) was given OTM (buccal cavity) or i.m. (quadriceps muscle) in six female neutered cats. Plasma samples were collected through a jugular catheter during a 24-h period. Plasma dexmedetomidine and buprenorphine concentrations were determined by liquid chromatography-tandem mass spectrometry. Plasma concentration-time data were fitted to compartmental models. For dexmedetomidine and buprenorphine, the area under the plasma concentration-time curve ( AUC) and the maximum plasma concentrations (C<subscript>max</subscript>) were significantly lower following OTM than following i.m. administration. For buprenorphine, time to reach C<subscript>max</subscript> was also significantly longer after OTM administration than after i.m. injection. Data suggested that dexmedetomidine (40 μg/kg) combined with buprenorphine (20 μg/kg) is not as well absorbed from the buccal mucosa site as from the intramuscular injection site. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01407783
- Volume :
- 38
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Veterinary Pharmacology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 101300523
- Full Text :
- https://doi.org/10.1111/jvp.12172