Back to Search
Start Over
Rates of Disease Progression among Human Immunodeficiency Virus--Infected Persons Initiating Multiple-Drug Rescue Therapy.
- Source :
- Journal of Infectious Diseases; 7/1/2003, Vol. 188 Issue 1, p137, 5p
- Publication Year :
- 2003
-
Abstract
- To characterize survival and to compare rates of disease progression to death of human immunodeficiency virus (HIV)-infected patients, between those initiating multiple-drug rescue therapy (MDRT) and those antiretroviral-inexperienced initiating triple-drug antiretroviral therapy (ART), we conducted a population-based analysis of HIV-infected men and women aged ≥18 years in British Columbia, Canada. Cumulative mortality rates were estimated by use of Kaplan-Meier methods, and Cox-proportional hazard regression was used to model the simultaneous effect of prognostic variables on survival. Cumulative mortality at 36 months was 14.2% ±2.0% and 10.9% ±1.0% for the MDRT and triple-drug ART groups, respectively (P =.105, log-rank test). After adjustment for other baseline prognostic variables, MDRT was found not to be a predictor of increased all-cause mortality (relative risk, 1.17; 95% confidence interval, 0.82-1.66) in multivariate analysis. Over the short-term, patients receiving MDRT had relatively low mortality. After adjustment for baseline prognostic factors, rates of survival were comparable with those in patients initiating triple-drug ART. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIV
MULTIDRUG resistance
THERAPEUTICS
MORTALITY
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 188
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 10102260
- Full Text :
- https://doi.org/10.1086/375781