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Advances in Translational Research in Neuro-oncology.

Authors :
Juan Fueyo
Gomez-Manzano, Candelaria
Yung, W. K. Alfred
Source :
Archives of Neurology; Mar2011, Vol. 68 Issue 3, p303-308, 6p
Publication Year :
2011

Abstract

During the last decade, we have witnessed several key advances in the field of neurooncology. First, there were conceptual advances in the molecular and cell biology of malignant gliomas including the discovery in 2004 of brain tumor stem cells. Second, the Cancer Genome Atlas project has been extremely useful in the discovery of new molecular markers, including mutations in the IDH1 gene, and has led to a new classification of gliomas based on the differentiation status and mesenchymal transformation. In addition, use of the 1p/19q marker and O<superscript>6</superscript>-methylguanine-DNA methyltransferase methylation status have been identified as guides for patient selection for therapies and represent the first steps toward personalized medicine for treating gliomas. Finally, progress has been made in treatment strategies including the establishment of temozolomide as the criterion standard for treating gliomas, the adoption of bevacizumab in the clinical setting, and developments in experimental biological therapies including cancer vaccines and oncolytic adenoviruses. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00039942
Volume :
68
Issue :
3
Database :
Complementary Index
Journal :
Archives of Neurology
Publication Type :
Academic Journal
Accession number :
100907637
Full Text :
https://doi.org/10.1001/archneurol.2010.293