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Basal Anxiety Negatively Correlates with Vulnerability to Ethanol-Induced Behavioral Sensitization in DBA/2J Mice: Modulation by Diazepam.

Authors :
Botia, Béatrice
Legastelois, Rémi
Houchi, Hakim
Naassila, Mickaël
Source :
Alcoholism: Clinical & Experimental Research; Jan2015, Vol. 39 Issue 1, p45-54, 10p
Publication Year :
2015

Abstract

Background Anxiety disorders predispose individuals to the development of alcohol dependence in humans. Surprisingly, whether anxiety is a trait influencing the development of alcohol-related behaviors in rodents remains controversial. Here, we addressed the hypothesis of a relationship between basal anxiety levels and the development of ethanol (Et OH)-induced behavioral sensitization ( EIBS), a model of neuroadaptations occurring after repeated Et OH exposure which is proposed to play a role in early and recurring steps of addiction. Methods Et OH-naïve DBA/2J mice were submitted to the elevated plus maze and light/dark box tests to evaluate their basal anxiety levels. Then, mice received daily intraperitoneal injection of saline or 2 g/kg Et OH for 10 days and locomotor activity was immediately monitored. Mice were then split into resistant and sensitized phenotypes based on their increase in locomotion. The relationship between basal anxiety and the development of sensitization was investigated. In addition, we tested the effect of an 8-day-long treatment with 4 mg/kg diazepam, a broad-spectrum benzodiazepine anxiolytic, on the expression of sensitization in both resistant and sensitized mice. Results For the first time, we showed that vulnerability to EIBS is negatively correlated with basal anxiety. Moreover, a diazepam treatment during EIBS procedure increased Et OH-induced hyperlocomotion of resistant mice after 1 week of withdrawal (but not immediately after) without any effect in the group of sensitized mice. Conclusions This study shows that, in mice, basal anxiety predicts the vulnerability to EIBS. Mice exhibiting low basal anxiety will develop higher EIBS than mice with elevated anxiety levels. Modulation of anxiety by a diazepam treatment during the development of EIBS enhances its expression after 1 week postinduction. Altogether, we demonstrated an inverse relationship between basal anxiety-like behaviors and EIBS vulnerability and that resistance to EIBS vanishes after anxiolytic treatment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
Volume :
39
Issue :
1
Database :
Complementary Index
Journal :
Alcoholism: Clinical & Experimental Research
Publication Type :
Academic Journal
Accession number :
100641308
Full Text :
https://doi.org/10.1111/acer.12595