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PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDES.
- Source :
- Euromediterranean Biomedical Journal; 01/01/2014, Vol. 9, p45-55, 11p, 10 Diagrams
- Publication Year :
- 2014
-
Abstract
- This review offers an overview of the synthesis of phosphonated isoxazolidinyl nucleosides, a new class of interesting and potentially antiviral/antitumor agents. The synthetic methodology relies on a 1,3-dipolar cycloaddition reaction as a key step. The cycloaddition process involves substituted nitrones, phosphonated nitrones, or nitrones containing functional groups easily convertible into a phosphonated group. Biological assays are presented, which show that phosphonated isoxazolidinyl nucleosides represent a new promising template of nucleoside analogues. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22797165
- Volume :
- 9
- Database :
- Complementary Index
- Journal :
- Euromediterranean Biomedical Journal
- Publication Type :
- Academic Journal
- Accession number :
- 100638146
- Full Text :
- https://doi.org/10.3269/1970-5492.2014.9.7