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Sulfadiazine-Chitosan Conjugates and Their Polyelectrolyte Complexes with Hyaluronate Destined to the Management of Burn Wounds.
- Source :
- Materials (1996-1944); 2015, Vol. 8 Issue 1, p317-338, 32p, 3 Color Photographs, 2 Black and White Photographs, 1 Diagram, 5 Charts, 4 Graphs
- Publication Year :
- 2015
-
Abstract
- In the present study polyelectrolyte complexes (PECs) based on new sulfadiazine-chitosan conjugates with sodium hyaluronate have been developed with potential use in treatment of burn wounds. The PECs were chemically characterized using Fourier Transform-Infrared Spectroscopy, Scanning Electon Microscopy and Near Infrared Chemical Imaging Technique. The swelling behavior and in vitro sulfadiazine release were also investigated. The antimicrobial activity was evaluated towards three bacterial strains: Escherichia coli, Listeria monocytogenes and Salmonella thyphymurium. The developed PECs demonstrated their antimicrobial efficiency against tested bacterial strains, the PECs containing sulfadiazine-modified chitosan being more active than PECs containing unmodified chitosan. [ABSTRACT FROM AUTHOR]
- Subjects :
- SULFADIAZINE
ANTI-infective agents
CHITOSAN
SPECTRUM analysis
MICROSCOPY
Subjects
Details
- Language :
- English
- ISSN :
- 19961944
- Volume :
- 8
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Materials (1996-1944)
- Publication Type :
- Academic Journal
- Accession number :
- 100604720
- Full Text :
- https://doi.org/10.3390/ma8010317