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Interleukin‑1 gene cluster variants in hemodialysis patients with end stage renal disease: An association and meta‑analysis.
- Source :
- Indian Journal of Nephrology; Jan/Feb2015, Vol. 25 Issue 1, p34-42, 9p, 1 Diagram, 4 Charts, 1 Graph
- Publication Year :
- 2015
-
Abstract
- We evaluated whether polymorphisms in interleukin (IL‑1) gene cluster (IL‑1 alpha [IL‑1A], IL‑1 beta [IL‑1B], and IL‑1 receptor antagonist [IL‑1RN]) are associated with end stage renal disease (ESRD). A total of 258 ESRD patients and 569 ethnicity matched controls were examined for IL‑1 gene cluster. These were genotyped for five single‑nucleotide gene polymorphisms in the IL‑1A, IL‑1B and IL‑1RN genes and a variable number of tandem repeats (VNTR) in the IL‑1RN. The IL‑1B − 3953 and IL‑1RN + 8006 polymorphism frequencies were significantly different between the two groups. At IL‑1B, the T allele of − 3953C/T was increased among ESRD (P = 0.0001). A logistic regression model demonstrated that two repeat (240 base pair [bp]) of the IL‑1Ra VNTR polymorphism was associated with ESRD (P = 0.0001). The C/C/C/C/C/1 haplotype was more prevalent in ESRD = 0.007). No linkage disequilibrium (LD) was observed between six loci of IL‑1 gene. We further conducted a meta‑analysis of existing studies and found that there is a strong association of IL‑1 RN VNTR 86 bp repeat polymorphism with susceptibility to ESRD (odds ratio = 2.04, 95% confidence interval = 1.48-2.82; P = 0.000). IL‑1B − 5887, +8006 and the IL‑1RN VNTR polymorphisms have been implicated as potential risk factors for ESRD. The meta‑analysis showed a strong association of IL‑1RN 86 bp VNTR polymorphism with susceptibility to ESRD. [ABSTRACT FROM AUTHOR]
- Subjects :
- ACADEMIC medical centers
CHI-squared test
CHRONIC kidney failure
CONFIDENCE intervals
CYTOKINES
GENETIC polymorphisms
HEMODIALYSIS
INTERLEUKIN-1
META-analysis
MULTIVARIATE analysis
GENETIC mutation
POLYMERASE chain reaction
SYSTEMATIC reviews
LOGISTIC regression analysis
GENOMICS
DATA analysis software
ODDS ratio
GENOTYPES
Subjects
Details
- Language :
- English
- ISSN :
- 09714065
- Volume :
- 25
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Indian Journal of Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 100543834
- Full Text :
- https://doi.org/10.4103/0971-4065.135350