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White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats.
- Source :
- Evidence-based Complementary & Alternative Medicine (eCAM); 2014, Vol. 2014, p1-8, 8p, 2 Charts, 6 Graphs
- Publication Year :
- 2014
-
Abstract
- This study attempted to explore the effects of white pepper and its major component piperine on puerarin administered to rats. Pharmacokinetic parameters of puerarin in rats were determined by oral administration (400mg/kg) or intravenous injection (40mg/kg) of puerarin, pretreated with or without white pepper and piperine given orally. Compared to the control group given oral puerarin only, the combined use of piperine (10 or 20mg/kg) increased the C<subscript>max</subscript> of puerarin by 1.30-fold or 1.64-fold and the AUC<subscript>0-∞</subscript> by 133% or 157%, respectively. In contrast, coadministration of white pepper (125 or 250mg/kg) decreased oral absorption of puerarin to 83% or 74%, respectively. On the other hand, pretreatment with piperine orally did not alter the intravenous pharmacokinetics of puerarin, while the AUC of puerarin after intravenous administration was increased by pretreatment with white pepper. The results indicate that pretreatment with piperine or pepper exerts different effects on pharmacokinetics of puerarin administrated via intragastric and intravenous routes. Therefore, it is suggested that the combined application of piperine or white pepper with puerarin should be carefully monitored for potential diet-drug interactions. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALTERNATIVE medicine
ANIMAL experimentation
BIOAVAILABILITY
BIOPHYSICS
COMPARATIVE studies
DRUG synergism
DRUG-food interactions
HIGH performance liquid chromatography
INTRAVENOUS injections
INTESTINAL absorption
RESEARCH methodology
MEDICINAL plants
ORAL drug administration
PROBABILITY theory
RATS
RESEARCH funding
SPICES
STATISTICAL hypothesis testing
T-test (Statistics)
PLANT extracts
ISOFLAVONES
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Volume :
- 2014
- Database :
- Complementary Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 100528063
- Full Text :
- https://doi.org/10.1155/2014/796890