Serial block-face scanning electron microscopy combined with double-axis electron beam tomography provides new insight into cellular relationships.

To evaluate the advantages of combination of two advanced electron microscopic technologies such as serial block-face scanning electron microscopy and double-axis electron beam tomography, we analyzed the three-dimensional morphology of cellular relationships between dendritic and plasma cells in the synovial membrane from patients with rheumatoid arthritis, using the combined approach. [ABSTRACT FROM PUBLISHER]