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Facile preparation of gadolinium(III) chelates functionalized carbon quantum dot-based contrast agent for magnetic resonance/fluorescence multimodal imagingt.
- Source :
- Journal of Materials Chemistry B; 2014, Vol. 2 Issue 34, p5541-5549, 9p, 1 Chart
- Publication Year :
- 2014
-
Abstract
- Suffering from high inherent toxicity generated from heavy metals in semiconductor quantum dots and a complex preparation process, the medical application of conventional gadolinium(III)/semiconductor quantum dot-based magnetic resonance/fluorescence multimodal imaging (MRI/FI) contrast agent has been limited. In this paper, a new kind of biocompatible carbon quantum dot functionalized by gadolinium(III) chelates (named as Gd(III)/CQDs) was obtained through one-step pyrolysis of gadopentetate monomeglumine, which provides simultaneously a carbon source and a gadolinium(III) source. The Gd(III)/CQDs show good magnetic resonance response and photoluminescence properties with longitudinal relaxation rate and quantum yield of 5.5-6.4 mM L[sup -1] S[sup -1] [Gd(III)%, 0.5 mM] and 2.6-8.9%, respectively. The Gd(III)/CQDs with diameters in the range of 2-3 nm can be well dispersed in deionized water, phosphate-buffered saline buffer solution or culture medium to form a stable dispersion, which with low cytotoxicity can penetrate into cells and show green fluorescence (excitation at 488 nm), presenting a great potential to be used as an MRI/FI contrast agent. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2050750X
- Volume :
- 2
- Issue :
- 34
- Database :
- Complementary Index
- Journal :
- Journal of Materials Chemistry B
- Publication Type :
- Academic Journal
- Accession number :
- 100487308
- Full Text :
- https://doi.org/10.1039/c4tb00709c