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A Case-Control Study of the Role of Human Papillomavirus in Oesophageal Squamous Cell Carcinoma in Australia.
- Source :
- Journal of Oncology; 2014, p1-7, 7p
- Publication Year :
- 2014
-
Abstract
- Objective. We investigate the prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) tissues compared to oesophageal tissue from healthy controls, in an Australian cohort. Methods. We conducted a hospital-based casecontrol study of 99 patients with OSCC and 100 healthy controls to examine the presence of HPV DNA. Paraffin tissues were tested using the PapType high-risk HPV detection and genotyping kit and with INNO-LiPA HPV Genotyping Extra. The biopsy samples were tested for HPV using a PCR-ELISA method based on the L1 consensus primer set PGMY09-PGMY11. Results. HPVDNA of the oncogenic genotype 16 was detected in 1/99 case specimens, a rate of 1010 per 100,000 (95% CI: 30-5500). All control specimens were negative forHPV. Significantly higher rates of smoking, other aerodigestive cancers, andmortalitywere seen among cases than controls. A pooled analysis of this study and the only other Australian case-control study found that 9/321 cases and 0/155 controls were positive for HPV. The pooled odds ratio for HPV being a risk factor for OSCC was 9.35 (95% CI: 0.47-190.33). Conclusion. Our results suggest that in this multifactorial cancer HPV may be an additional risk factor; although a larger, better powered study is needed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16878450
- Database :
- Complementary Index
- Journal :
- Journal of Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 100484017
- Full Text :
- https://doi.org/10.1155/2014/236482