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Freeze-dried chitosan–sodium hyaluronate polyelectrolyte complex fibers as tissue engineering scaffolds.
- Source :
- New Journal of Chemistry; 2014, Vol. 38 Issue 3, p1211-1217, 7p
- Publication Year :
- 2014
-
Abstract
- The present work was focused on the preparation and characterization of polyelectrolyte complex (PEC) fibers based on the natural oppositely charged biopolymers, chitosan and sodium hyaluronate, via a freeze-drying method. The physical structure and chemical properties of the freeze-dried fibers were characterized by means of Fourier transform infrared spectroscopy (FT-IR), solid-state <superscript>13</superscript>C nuclear magnetic resonance (<superscript>13</superscript>C-NMR) and X-ray diffraction (XRD). The morphology, size, and surface structure of the freeze-dried PEC fibers were observed by means of scanning electron microscopy (SEM). An indirect in vitro cytotoxicity test showed the extracts of fibers had no significant effects on cell viability. Moreover, an in vitro cytocompatibility test exhibited cell population and spreading tendency, suggesting the fibers were non-toxic to L929 cells. All the results indicated that such freeze-dried PEC fibers might have potential applications in tissue engineering scaffolds. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHITOSAN
TISSUE scaffolds
TISSUE engineering
POLYELECTROLYTES
BIOPOLYMERS
Subjects
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 38
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 100402604
- Full Text :
- https://doi.org/10.1039/c3nj00701d