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Visible light-triggered nitric oxide release from near-infrared fluorescent nanospheric vehicles.
- Source :
- Analyst; 2014, Vol. 139 Issue 13, p3398-3406, 9p
- Publication Year :
- 2014
-
Abstract
- Bifunctional Ag<subscript>2</subscript>S QDs@CS-RBS nanospheres with ultralow toxicity for biomedical use were fabricated. These are capable of releasing NO under irradiation of visible light and emitting in near-infrared (NIR) region fluorescence excited by NIR laser under physiological environment. Glutathiose (GSH)-capped Ag<subscript>2</subscript>S QDs were synthesized and encapsulated by chitosan (CS) to form NIR fluorescent Ag<subscript>2</subscript>S QDs@CS nanospheres. A type of iron/sulfur/-nitrosyl cluster, Roussin's black salt anion Fe<subscript>4</subscript>S<subscript>3</subscript>(NO)<subscript>7</subscript><superscript>−</superscript> (RBS) was conjugated with the Ag<subscript>2</subscript>S QDs@CS to obtain Ag<subscript>2</subscript>S QDs@CS-RBS nanospheres. A variety of characterization methods were employed to analyze the nanospheres. In vitro cell imaging and in vivo mice imaging experiments demonstrated that the Ag<subscript>2</subscript>S QDs@CS-RBS nanospheres could emit readily observable NIR fluorescence and deliver NO in living cells and small animals. The NIR imaging of the Ag<subscript>2</subscript>S QDs@CS nanospheres would not interfere with the light-triggered NO release from them, as the excitation lasers needed for these two functions are in different wavelength regions. This work provides new perspectives for the application of multifunctional nano-structured materials in diagnostics and bioimaging. [ABSTRACT FROM AUTHOR]
- Subjects :
- NITRIC oxide
FLUORESCENCE
VEHICLES
WAVELENGTH division multiplexing
IMAGING systems
Subjects
Details
- Language :
- English
- ISSN :
- 00032654
- Volume :
- 139
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 100393477
- Full Text :
- https://doi.org/10.1039/c4an00275j