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Marked anti-tumor effects of CD8+CD62L+ T cells from melanoma-bearing mice.
- Source :
- Immunological Investigations; Feb2015, Vol. 44 Issue 2, p147-163, 17p
- Publication Year :
- 2015
-
Abstract
- CD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells have been shown to play pivotal roles in anti-viral immunity, chronic myeloid leukemia and renal cell carcinoma. Recently, CD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells from naïve mice (nCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells) have shown superior anti-tumor properties in melanoma-bearing mice. Considering that antigen-specific memory T cells have shown to possess more potent immunity than non-specific memory T cells, we hypothesized that CD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells from tumor-bearing individuals (mCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells) might have superior anti-tumor effect than nCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells. Therefore, we investigated phenotypes, functions and the in vivo distribution of mCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells in tumor-bearing mice. We found that, while keeping the features of central memory T cells, the frequency of mCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cell in the spleen of tumor-bearing mice was significantly higher than that the one of nCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cell in naive mice. Moreover, we demonstrated that mCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells had higher proliferation rate and IFN-γ production than nCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells, in vitro. We performed adoptive transfer of mCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells into melanoma-bearing mice and tracked them in spleen, lymph nodes and in melanoma tissues. Our results show that mCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells had stronger in vivo anti-tumoral activity than nCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells. This study highlights the therapeutic potential of mCD8<superscript>+</superscript>CD62L<superscript>+</superscript> T cells in the immunotherapy of melanoma and possibly other tumors. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTINEOPLASTIC agents
CD8 antigen
MELANOMA
LABORATORY mice
T cells
ANTIVIRAL agents
Subjects
Details
- Language :
- English
- ISSN :
- 08820139
- Volume :
- 44
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Immunological Investigations
- Publication Type :
- Academic Journal
- Accession number :
- 100372707
- Full Text :
- https://doi.org/10.3109/08820139.2014.944980