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Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging.
- Source :
- Chemical Communications; 2015, Vol. 51 Issue 5, p881-884, 4p
- Publication Year :
- 2015
-
Abstract
- Starting from 7-hydroxyisoflavones, we developed a new class of fluorescent scaffolds, 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs, M<subscript>W</subscript> ~ 205.19, λ<subscript>ab</subscript> ~ 350 nm, λ<subscript>em</subscript> ~ 450 nm) via a trial and error process. AMHCs have the advantages of being a small molecular moiety, having strong fluorescence in basic buffers, reasonable solubility and stability, non-toxicity, and are conveniently linked to pharmacophores. AMHCs were successfully used in fluorescence microscopy imaging of cells and tissues. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 51
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 100004111
- Full Text :
- https://doi.org/10.1039/c4cc06762b