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Gold Nanoparticle Mediated Radiation Therapy using MV Energy X-ray
- Publication Year :
- 2023
-
Abstract
- Reactive oxygen species (ROS), which are principally responsible for cell damage under x-ray sources, are generated more abundantly in the presence of gold nanoparticles (AuNPs), enhancing the effect of radiation in biological models. The uncoated AuNPs exhibit a tendency to agglomerate in the presence of salt, ubiquitous in cell culture media, serum, and plasma. Thus, appropriate surface coatings are necessary for use in clinical applications. We hypothesize that biocompatible coating on AuNPs may augment ROS generation and ultimately cause more damage to the cancer cells. Here we examine the effectiveness of silica coating AuNPs surface (Au@SiO2), polyvinyl alcohol (PVA) coated AuNPs and bovine serum albumin (BSA) coated AuNPs, comparing the ROS production efficiency under MV x-ray irradiation in in vitro such as aqueous solutions of Au@SiO2 NPs, Au@PVA NPs, Au@BSA NPs, uncoated AuNPs, and water-only samples as well as using MCF-7 and BT-20 cell media loaded with Au@SiO2 NPs, Au@PVA NPs, Au@BSA NPs and uncoated AuNPs.
Details
- Language :
- English
- Database :
- OpenDissertations
- Publication Type :
- Dissertation/ Thesis
- Accession number :
- ddu.oai.etd.ohiolink.edu.toledo1682976270909297