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Design and synthesis of 6-(6-D-ribitylamino-2,4-dihydroxypyrimidin-5-yl)-1-hexyl phosphonic acid, a potent inhibitor of lumazine synthase.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Jan 04; Vol. 9 (1), pp. 39-42. - Publication Year :
- 1999
-
Abstract
- A novel inhibitor of lumazine synthase, the penultimate enzyme in the biosynthesis of riboflavin, has been synthesized. The inhibitor was designed by computer graphics molecular modeling using a hypothetical structure of the enzyme-inhibitor complex. The new compound is relatively potent when compared with the known inhibitors, and displays a KI of 109 microM.
- Subjects :
- Bacillus subtilis drug effects
Bacillus subtilis enzymology
Binding Sites
Capsid drug effects
Crystallography, X-Ray
Drug Design
Enzyme Inhibitors metabolism
Models, Molecular
Molecular Structure
Multienzyme Complexes metabolism
Organophosphonates chemistry
Riboflavin Synthase metabolism
Software
Thymidine chemical synthesis
Thymidine chemistry
Thymidine pharmacology
Enzyme Inhibitors chemical synthesis
Enzyme Inhibitors pharmacology
Multienzyme Complexes antagonists & inhibitors
Organophosphonates chemical synthesis
Organophosphonates pharmacology
Riboflavin Synthase antagonists & inhibitors
Thymidine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 9990453
- Full Text :
- https://doi.org/10.1016/s0960-894x(98)00687-8