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(Pro)insulin and insulin-like growth factor I complementary expression and roles in early development.
- Source :
-
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology [Comp Biochem Physiol B Biochem Mol Biol] 1998 Sep; Vol. 121 (1), pp. 13-7. - Publication Year :
- 1998
-
Abstract
- Evidence that the insulin-like growth factors play a role in embryonic as well as postnatal growth and central nervous system development has accumulated recently from studies using knock-out mice models. However, no effects of IGF-I and II have been demonstrated prior to organogenesis in these studies. We summarize here results supporting the role of insulin (or its precursor proinsulin) in vertebrate development prior to the expression of IGFs. (Pro)insulin mRNA is expressed in the chick embryo during neurulation and early organogenesis and its inhibition by antisense oligodeoxynucleotides increase apoptosis. In another system, proliferative neuroretina, (pro)insulin expression predominates over IGF-I expression. Modulation of apoptosis by (pro)insulin in retina may be largely responsible for the observed stimulation of DNA synthesis and neuronal differentiation. These effects are elicited as well by IGF-I, expressed later in neuroretina. Thus, these polypeptides have complementary expression in early embryos which suggests coordinated actions during development.
- Subjects :
- Animals
Apoptosis drug effects
Chick Embryo
Gene Expression Regulation, Developmental
Mice
Mice, Knockout
Nervous System embryology
Nervous System metabolism
Oligonucleotides, Antisense genetics
Oligonucleotides, Antisense pharmacology
RNA, Messenger genetics
RNA, Messenger metabolism
Insulin genetics
Insulin-Like Growth Factor I genetics
Proinsulin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1096-4959
- Volume :
- 121
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 9972280
- Full Text :
- https://doi.org/10.1016/s0305-0491(98)10105-0