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Detection of colorectal liver metastases: prospective comparison of unenhanced and ferumoxides-enhanced magnetic resonance imaging at 1.5 T, dual-phase spiral CT, and spiral CT during arterial portography.
Detection of colorectal liver metastases: prospective comparison of unenhanced and ferumoxides-enhanced magnetic resonance imaging at 1.5 T, dual-phase spiral CT, and spiral CT during arterial portography.
- Source :
-
Magma (New York, N.Y.) [MAGMA] 1998 Dec; Vol. 7 (2), pp. 76-87. - Publication Year :
- 1998
-
Abstract
- The purpose of this study was to compare the efficacy of unenhanced and ferumoxides-enhanced magnetic resonance imaging with that of dual-phase spiral CT and spiral CT during arterial portography (CTAP) for the detection of colorectal liver metastases. Fourteen patients with liver metastases candidates for partial hepatectomy were examined with dual-phase spiral CT, unenhanced and ferumoxides-enhanced MR imaging at 1.5 T, and spiral CTAP. Imaging tests were read blinded, prospectively, quantitating number of lesions excepting CTAP which used US to exclude cysts. Subsequent intraoperative US and pathologic findings were correlated with preoperative imaging results. At surgery, 36 lesions 0.5-13 cm in diameter (mean+/-standard deviation, 2.9+/-2.1 cm) were identified. Dual-phase spiral CT depicted 21/36 (58%); precontrast MR imaging, 19/36 (53%); ferumoxides-enhanced MR imaging, 30/36 (83%); and spiral CTAP, 34/36 (94%) lesions. Ferumoxides-enhanced MR imaging was significantly more sensitive than spiral CT and unenhanced MR imaging (P < 0.01). The difference in sensitivity between ferumoxides-enhanced MR imaging and spiral CTAP was not statistically significant (P> 0.1). Spiral CTAP, however, depicted nine false-positive lesions (2 hemangiomas, 7 perfusion defects). The positive predictive value was 79% for spiral CTAP and 100% for combined pre- and postcontrast MR imaging. We conclude that ferumoxides-enhanced MR imaging is superior to unenhanced MR imaging and biphasic spiral CT for depiction of colorectal liver metastases. Further investigation is needed to clarify whether MR imaging with use of ferumoxides might replace spiral CTAP for preoperative evaluation of liver resection candidates.
- Subjects :
- Adult
Aged
Contrast Media administration & dosage
Dextrans
False Positive Reactions
Female
Ferrosoferric Oxide
Hepatectomy
Humans
Iron administration & dosage
Liver Neoplasms secondary
Magnetic Resonance Imaging statistics & numerical data
Magnetite Nanoparticles
Male
Middle Aged
Oxides administration & dosage
Portography
Prospective Studies
Sensitivity and Specificity
Tomography, X-Ray Computed statistics & numerical data
Colorectal Neoplasms
Liver Neoplasms diagnosis
Liver Neoplasms diagnostic imaging
Magnetic Resonance Imaging methods
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 0968-5243
- Volume :
- 7
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Magma (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 9951768
- Full Text :
- https://doi.org/10.1007/BF02592232