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Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1.
- Source :
-
International journal of cancer [Int J Cancer] 1999 Jan 18; Vol. 80 (2), pp. 219-30. - Publication Year :
- 1999
-
Abstract
- Thirty-nine tumor-bearing patients with metastatic melanoma were treated with 3 subcutaneous injections of the MAGE-3.A1 peptide at monthly intervals. No significant toxicity was observed. Of the 25 patients who received the complete treatment, 7 displayed significant tumor regressions. All but one of these regressions involved cutaneous metastases. Three regressions were complete and 2 of these led to a disease-free state, which persisted for more than 2 years after the beginning of treatment. No evidence for a cytolytic T lymphocyte (CTL) response was found in the blood of the 4 patients who were analyzed, including 2 who displayed complete tumor regression. Our results suggest that injection of the MAGE-3.A1 peptide induced tumor regression in a significant number of the patients, even though no massive CTL response was produced.
- Subjects :
- Adult
Aged
Antigen Presentation
Antigens, Neoplasm adverse effects
Antigens, Neoplasm genetics
Disease Progression
Female
Genetic Code
Humans
Male
Melanoma secondary
Middle Aged
Neoplasm Proteins adverse effects
Neoplasm Proteins genetics
Antigens, Neoplasm therapeutic use
HLA-A1 Antigen immunology
Immunotherapy
Melanoma therapy
Neoplasm Proteins therapeutic use
Remission Induction methods
Subjects
Details
- Language :
- English
- ISSN :
- 0020-7136
- Volume :
- 80
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 9935203
- Full Text :
- https://doi.org/10.1002/(sici)1097-0215(19990118)80:2<219::aid-ijc10>3.0.co;2-s