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Coprophilin: an anticoccidial agent produced by a dung inhabiting fungus.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1998 Dec 15; Vol. 8 (24), pp. 3439-42. - Publication Year :
- 1998
-
Abstract
- Coprophilin, a decalin pentanedienoic acid methyl ester, was isolated from an unidentified fungus by bioassay guided separation. It inhibited (MIC = 1.5 microM) the growth of Eimeria tenella in an in vitro assay. The isolation, structure elucidation, absolute stereochemistry and biology are described.
- Subjects :
- Alkenes chemical synthesis
Alkenes chemistry
Animals
Cattle
Cell Line
Coccidiostats chemistry
Esters chemical synthesis
Esters chemistry
Feces microbiology
Molecular Structure
Spectrometry, Mass, Fast Atom Bombardment
Stereoisomerism
Alkenes pharmacology
Coccidiostats pharmacology
Eimeria tenella drug effects
Esters pharmacology
Fungi metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 8
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 9934448
- Full Text :
- https://doi.org/10.1016/s0960-894x(98)00629-5